Update on emerging drugs for cancer cachexia

KT Murphy; GS Lynch

Journal article

Update on emerging drugs for cancer cachexia

KT Murphy, GS Lynch

Expert Opinion on Emerging Drugs | TAYLOR & FRANCIS LTD | Published : 2009

DOI: 10.1517/14728210903369351

Abstract

Cancer cachexia is a complex syndrome that describes the progressive muscle wasting and weakness in many cancer patients. Muscle wasting reduces the ability of affected patients to perform the tasks of daily living and causes severe fatigue, leading to a reduction in quality of life. Cancer cachexia reduces patient response to anti-neoplastic treatments, increases the risk of postoperative complications and accounts for > 20% of cancer-related deaths. The pathogenesis of cancer cachexia is multifactorial and includes anorexia, inflammation, metabolic disturbances and enhanced muscle proteolysis, and each of these presents as a potential therapeutic target for ameliorating cancer cachexia. Ob..

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University of Melbourne Researchers

Gordon Lynch Author

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Grants

Awarded by Australian Research Council

Awarded by National Health and Medical Research Council of Australia

Awarded by Muscular Dystrophy Association

Funding Acknowledgements

[ "The Basic and Clinical Myology Laboratory gratefully acknowledges the generous research funding received from the Australian Research Council Discovery-Project funding scheme (DP0772781), National Health and Medical Research Council of Australia (NHMRC 454561, 509313, 566818, 566820), Muscular Dystrophy Association (USA, 4167), Association Francaise contre les Myopathies, Rebecca L. Cooper Medical Research Foundation, Pfizer, Inc. (USA), F. Hoffmann-La Roche Ltd (Switzerland) and Merck & Co., Inc. (USA).", "KT Murphy is a Peter Doherty Research Fellow of the National Health and Medical Research Council (Australia)." ]